This Renaissance building rises on the eastern side of the square just opposite the Town Hall. Girolamo Riario, lord of Imola, built it between 1480 and 1484 as his noble residence. It has an elegant brick façade featuring 14 Gothic arches supported by grey sandstone slender columns with fine capitals and pulvinos.

The first floor windows, the portico's arches and the admirable cornice display beautiful terracotta decorations. Following the fall of the Riario-Sforza lordship, the building ceased to be a residence and today its ground floor houses a number of shops. Its present name comes from the Sersanti family who acquired it at the end of the 18th century. 
Worth special mention is the main hall with a fine lacunar ceiling. It is used for conferences and concerts.